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Re: Cancer clinical trial

Posted: Fri Aug 10, 2018 12:03 pm
by connie
Still rooting for Max, what's the procedure for his further treatments?

Re: Cancer clinical trial

Posted: Sat Aug 11, 2018 11:37 pm
by maxs_mommy
His white cells are back up so we're on a week of Doxy. Apparently this is not abnormal but we won't be doing another treatment this month based on the bloodwork and life's schedule. He yelps in pain like something's poking him in the mouth once in a while and it's clearly uncomforatable but of course he won't allow anyone to look into his mouth without sedation. Sigh. I have a appointment on Monday for a nail trim and I"m going to have a convo with his regular vet about this.

Re: Cancer clinical trial

Posted: Mon Aug 13, 2018 7:04 am
by connie
Paws and fingers here are all crossed for you and Max, it's got to be like walking on a high-wire.

Re: Cancer clinical trial

Posted: Mon Aug 13, 2018 7:06 am
by SherriA
I hope your vet has some ideas. Poor Max and poor you. This is such a balancing act.

Re: Cancer clinical trial

Posted: Wed Aug 22, 2018 11:41 am
by maxs_mommy
So the next treatment was supposed to be on Friday but I nixed that idea because we're going on vaca on Sunday and I didn't want to have side effects for the inlaws and pet sitter to manage. Last time the side effects manifested for about a week after and now he's stable. Now the next treatment is the 7th of Sept. As much as I hate waiting, I'd rather be the one to manage any weirdnesses.

Re: Cancer clinical trial

Posted: Thu Aug 23, 2018 5:30 am
by connie
Sounds like the side effects are a consideration in planning the treatment -- that's too bad, but probably to be expected. What are the objectives of the clinical trial?

Re: Cancer clinical trial

Posted: Thu Aug 23, 2018 5:59 am
by SherriA
That sounds like a sound plan. I'm keeping my fingers crossed that the side effects are manageable and this treatment helps sweet Max

Re: Cancer clinical trial

Posted: Fri Aug 24, 2018 7:25 am
by MaisyPancakes
Good plan! :) Sending no-mo-side-effects vibes to the softest curly curl boy!

Re: Cancer clinical trial

Posted: Fri Aug 24, 2018 9:46 am
by maxs_mommy
Connie, the study goals are to kill, or at least substantially reduce, the mouth tumor and reduce the mets. I took him in for a nail trim and my vet got a glimpse of the tumor this morning. She thinks it's gotten flatter and smaller but we'll see for certain when he goes on the 7th and can get a good look at it under gas. The main tumor was growing toward the back of the mouth toward the throat so that's why the intubation and gas. He is gaining weight, up 1.5# in a month which is huge, he needed to gain because he had nothing to lose and was. Ideally he'd be between 23-25 lbs so we're in range with the weight gain. Nausea was the known side effect for this which we had some of but because the tumor is in the mouth there was some sensitivity and pain which we've got a handle on but I'm not going to ask someone else to manage any weirdness.
Sorry this is rambling. I'm exhausted from getting my butt kicked with work last night.

Re: Cancer clinical trial

Posted: Fri Aug 24, 2018 9:59 am
by MaisyPancakes
YAY for weight gain and shrinkage/flattage!!! That's huge! <3 :thumbup: :laugh: Hope you get some rest!

Re: Cancer clinical trial

Posted: Sat Aug 25, 2018 11:33 am
by JudyL
I'm glad you are seeing some positive results out of this despite the side effects! At least you have ways to minimize those, and I completely understand your decision to not place that burden on those caring for him in your absence.

Re: Cancer clinical trial

Posted: Tue Oct 02, 2018 10:41 am
by maxs_mommy
Today was the 3rd treatment and, after two weeks of normal range white cells, the tumor has shrunk 1 cm in both directions. Hooray! They said it's not uncommon for the tumor to become infected at some point during treatment but I'm hoping we won that rodeo already with the first round. I'll pick him up shortly and let him sleep off the anesthesia.

Re: Cancer clinical trial

Posted: Tue Oct 02, 2018 10:46 am
by MaisyPancakes
Yessss!! That is a ton of shinkage!! Go shrinkasaurus Max! :D Hope he has some awesome dreams sleeping off the zonks. :)

Re: Cancer clinical trial

Posted: Wed Oct 03, 2018 8:35 am
by JudyL
Wonderful news! I hope you continue to see more shrinking. How many sessions are left?

Re: Cancer clinical trial

Posted: Wed Oct 03, 2018 6:56 pm
by Jen
Wow, that's awesome!!!

Re: Cancer clinical trial

Posted: Wed Oct 03, 2018 11:50 pm
by maxs_mommy
I was told there's not a definitive number of treatments, we'll go until it doesn't work or the tumor is gone. He was so zonked from the anesthesia yesterday that he was snoring as I carried him to the car. Something about the treatment also seems to cause diarrhea because he had 4 bouts of poopsplosion last night. He seems to have rebounded today with alertness and the gut aliens have mostly moved on, thanks dog. Blood draw on Tuesday for white cell count and maybe another treatment toward the end of the month.

Re: Cancer clinical trial

Posted: Sun Oct 07, 2018 4:40 pm
by connie
Wow, how great that he's gotten that result so far! Sorry about the poop situation, I guess you have to take the bad with the good. :sick:

Re: Cancer clinical trial

Posted: Mon Oct 08, 2018 5:27 am
by SherriA
Those are amazing results!

Re: Cancer clinical trial

Posted: Fri Oct 12, 2018 1:35 am
by maxs_mommy
In this week's edition of "weird bloodwork" we have slight anemia and higher ALT & ALP. ALT is always out of range because of the Cushing's but it's higher still, apparently. Hepatic support and B complex vitamins on board. Recheck on Tuesday.

Re: Cancer clinical trial

Posted: Sat Oct 13, 2018 7:39 am
by emmas_mom
Glad to read the tumor is shrinking. I hope the side effects diminish quickly.

Re: Cancer clinical trial

Posted: Mon Oct 15, 2018 9:19 am
by SherriA
fingers crossed for better liver numbers tomorrow!

Oliver had ALP through the roof the entire time I had him. I tested for everything under the sun and we never found what was causing it but it also never seemed to affect him. Hopefully this is a blip, but if it isn't my fingers are crossed that Max will not be bothered by it.

Re: Cancer clinical trial

Posted: Tue Oct 16, 2018 11:17 pm
by maxs_mommy
The trial vet was nice enough to send all the labs to my vet for a comparison arc/graph. Max is doing well on his supplements and did a blood recheck today.

Re: Cancer clinical trial

Posted: Wed Oct 17, 2018 8:32 am
by MaisyPancakes
Yaaay, I'm so glad that this trial has been yielding super great results for the Max!!

Re: Cancer clinical trial

Posted: Thu Oct 18, 2018 5:05 am
by SherriA
Excellent news!

Re: Cancer clinical trial

Posted: Fri Oct 19, 2018 12:01 am
by maxs_mommy
And now something else is weird. I expected to have another treatment Tuesday but it looks like we're going in for more blood work instead. I just got a call from the receptionist today to schedule. I'm going to follow up with the vet on Friday.

Re: Cancer clinical trial

Posted: Fri Oct 19, 2018 9:45 am
by MaisyPancakes
Sending "just too much Maxness in the blood and nothing bad-weird" vibes! You'll do the bloodwork on Tues?

Re: Cancer clinical trial

Posted: Fri Oct 19, 2018 9:53 pm
by maxs_mommy
We do more bloodwork Tuesday. I got a call today, his RBC's are back to WNL, the ALP is coming down but still high.

Re: Cancer clinical trial

Posted: Tue Oct 23, 2018 7:27 am
by SherriA
coming down is good, though!

Re: Cancer clinical trial

Posted: Mon Oct 29, 2018 8:14 pm
by maxs_mommy
Another treatment today, another 1 cm of shrink radially across the tumor and some shrinking of depth of the tumor so we forge on. No infections of the tumor and if we can only get the liver levels down we'll be good. Boy wonder is snoozing like the dead but did much better with the anesthesia. He was ambulatory when I picked him up which is an improvement over last time, ;) .

Re: Cancer clinical trial

Posted: Fri Nov 02, 2018 3:53 pm
by SherriA
I missed this when you posted it, but hooray for continued shrinkage! I'm glad that the anesthesia was easier on him this time. Fingers crossed for those liver levels.