Galliprant

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LisaT_II
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Galliprant

Postby LisaT_II » Fri Jan 20, 2017 11:42 am

I thought I would spread the word....

A new canine NSAID came on the market last March, called galliprant. It apparently is not a COX inhibitor so it works differently than the others.

I was reading the insert: http://www.aratana.com/Galliprant
And I saw that it's a p-glycoprotein substrate which would mean that it shouldn't be used in mdr1 dogs. The mdr1 lab has not tested yet in canines (I contacted the lab and it appears it was tested with the human version and they have not yet tested it for dogs).

So please get the word out if you see friends mentioning this drug on FB, etc., that it shouldn't be used in mdr1 dogs until the VCPL tests it, and, as with HW treatment, dogs should be tested for the mdr1 mutation before using it, particularly if it's a susceptible breed or any type of a mix.

I think it's incredibly IRRESPONSIBLE for this drug to be released without being fully tested.
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LisaT_II
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Re: Galliprant

Postby LisaT_II » Fri Jan 20, 2017 11:45 am

I will add, their website also has no caution.

https://www.elanco.us/galliprant/vet/
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Re: Galliprant

Postby MaisyPancakes » Mon Jan 23, 2017 8:59 am

I'll ask my rehab vet about it! Last year, she thought MP was a good candidate and tried to get some for us, but the rep she was in contact with said that the drug won't be released until early 2017, so it wasn't available then. She was considering this drug for us because we'd been wanting to avoid NSAIDs if we can help it (doing Metacam for now), and to her, the MoA seemed to make sense and the data she had seen looked safe (for us).

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LisaT_II
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Re: Galliprant

Postby LisaT_II » Tue Jan 24, 2017 11:41 pm

I think it just may be coming available now, i'm not sure. Definitely good to have other options. If you try it, keep usposted on how it goes!
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etexlady
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Re: Galliprant

Postby etexlady » Thu Feb 02, 2017 7:40 am

Interesting information - thanks for sharing. My 10 year old toy poodle was prescribed Rimadyl about a year ago to help with pain from a subluxing patella. I also put her on Cosequin at the same time and she has done extremely well. At her annual exam last week her vet recommended we discontinue the Rimadyl even though blood work did not indicate any of the bad side effects. The vet said it was just a risky drug to use long-term. Since stopping the Rimadyl my dog is stiff and limps somewhat when getting up. Likely arthritis. I'm thinking of trying T-Relief (Zeel) or Boswellia. Has anyone tried either of these with any success? She goes back to the Vet in a couple of weeks so I'll be sure to ask about the Galliprant as well.

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Re: Galliprant

Postby MaisyPancakes » Thu Feb 02, 2017 7:56 am

Lisa, I talked to my vet and she asked her colleague who had worked with the drug company. According to her, their test did include dogs from high-risk breeds—but they were not specifically tested/determined to be MDR1—but nothing bad happened to any of the high-risk dogs. So basically, as you said, not tested to be MDR1 safe; just that the drug didn't produce adverse effects on possible MDR1 dogs. My vet and her colleague both thought that the MDR1 safety should be properly established, so hopefully Aratana will do something about it.

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LisaT_II
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Re: Galliprant

Postby LisaT_II » Sat Feb 04, 2017 2:02 pm

I went back and looked at the field study and certainly no way to tell what was going on there, or why the dogs that didn't finish the study didn't. The long term toxicology study was done in Beagles only, according to the insert. The mdr1 lab said that they weren't able to get the raw drug to study - I guess I put that on Aratana... I think it's just completely irresponsible.

Thanks for the follow-up, interesting to hear the word of mouth from that end of the study.
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Re: Galliprant

Postby MaisyPancakes » Wed Mar 01, 2017 5:15 am

Lisa, I'm looking at this on my phone with no sleep and a stuffed nose, so my brain has processed very little :tongue: — but I'm wondering if these docs might mention some of the things missing in the insert? I noticed that they were hard to find on a laypersons internet search; my vets may be able to find more in their vet databases/groups.

http://www.2ndchance.info/arthritis2-Ra ... ra2016.pdf

http://www.2ndchance.info/arthritis2-Ra ... ra2015.pdf

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LisaT_II
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Re: Galliprant

Postby LisaT_II » Wed Mar 01, 2017 7:03 am

I didn't read the articles, but did a search in both for the words glycoprotein and also substrate, and nothing came up. The mdr1 lab did say that they haven't been able to get the raw drug in order to test it, which makes me think that the drug company could have it tested if they wanted to?
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Re: Galliprant

Postby MaisyPancakes » Wed Mar 01, 2017 7:48 am

Oh I see. I was thinking that the links I posted had some info about dropouts. (One ended up being dx-ed w/cancer or something, IIRC.) It's too bad that they didn't do anything about the MRD1 dogs. I would have thought you'd be required to. :/

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LisaT_II
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Re: Galliprant

Postby LisaT_II » Thu Mar 02, 2017 12:45 am

Oh, I didn't read close enough to see what else helpful is there, I think we were looking for different things!
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